Improving function and quality of life in people with dementia


deb-barnes Deborah E.  Barnes, PhD, MPH, Principal Investigator

Dr. Barnes is Associate Professor of Psychiatry and Epidemiology & Biostatistics at the University of California, San Francisco (UCSF); Research Health Sciences Specialist at the San Francisco Veterans Affairs Medical Center (SFVAMC); and Senior Investigator for Tideswell at UCSF. Dr. Barnes’ research focuses on identifying risk factors for cognitive impairment and dementia in older adults; developing risk prediction models to identify those with higher risk; and testing strategies to reduce risk, delay onset and slow progression of symptoms. Dr. Barnes and colleagues have been systematically developing and testing the PLIE Program since 2010, including two ongoing studies: PLIÉ-VA and Paired PLIÉ.

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wmehling Wolf E. Mehling, MD, Co-Investigator, PLIÉ-VA and Co-Principal Investigator, Paired PLIÉ

Dr. Mehling is Associate Professor of Clinical Family and Community Medicine at UCSF and a faculty member at the Osher Center for Integrative Medicine. His research focuses on body-oriented complementary therapies and mind-body interactions. Dr. Mehling oversees development and implementation of the exercise intervention component of the study.

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mchesney Margaret A. Chesney, PhD, Co-Investigator, PLIÉ-VA and Paired PLIÉ

Dr. Chesney is Professor of Medicine, Osher Foundation Distinguished Professor in Integrative Medicine and former Director of the Osher Center for Integrative Medicine at UCSF. She was Deputy Director of the National Center of Complementary and Alternative Medicine at the National Institutes of Health from 2003-2008 and has extensive knowledge and expertise related to alternative approaches to health and well-being. Dr. Chesney provides guidance related to the integrative and psychological aspects of the program.

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kyaffe Kristine Yaffe, MD, Co-Investigator, PLIÉ-VA

Dr. Yaffe is Chief of Neuropsychiatry and Director of the Memory Disorders Clinic at SFVA and a Professor of Psychiatry, Neurology and Epidemiology & Biostatistics at UCSF. She is an international leader in identification of risk factors for cognitive decline and dementia and has been PI or site-PI of several clinical trials in individuals with cognitive impairment or dementia. She was a co-investigator on the PLIÉ pilot study.

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gabrams Gary M. Abrams, MD, Co-Investigator, PLIÉ-VA

Dr. Abrams is the Rehabilitation Section Chief at SFVA, Director of the Neurorehabilitation Clinic at UCSF, and Professor of Clinical Neurology at UCSF. He has extensive expertise related to techniques for neural compensation and repair, particularly related to the functional consequences of acquired brain injury.

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bosc John W. Boscardin, PhD, PLIÉ-VA and Paired PLIÉ

Dr. Boscardin is a biostatistician and Professor of Medicine and Epidemiology & Biostatistics at UCSF. He and Dr. Barnes have collaborated on numerous projects.

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nByl Linda L. Chao, PhD Co-Investigator, PLIÉ-VA and Paired PLIÉ

Dr. Chao is an Associate Professor of Radiology and Biomedical Imaging and in the Department of Psychiatry at UCSF. Dr. Chao has extensive expertise performing imaging studies in older adults including those with cognitive impairment. She is performing a neuroimaging sub-study in current study participants to examine the effects of the program on brain structure and function.

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